The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in southeast Asia: A cluster randomised trial

L von Seidlein; TJ Peto; J Landier; TN Nguyen; R Tripura; K Phommasone; T Pongvongsa; KM Lwin; L Keereecharoen; L Kajeechiwa; MM Thwin; DM Parker; J Wiladphaingern; S Nosten; S Proux; V Corbel; N Tuong-Vy; TL Phuc-Nhi; DH Son; PN Huong-Thu; NTK Tuyen; NT Tien; LT Dong; D Van Hue; HH Quang; C Nguon; C Davoeung; H Rekol; B Adhikari; G Henriques; P Phongmany; P Suangkanarat; A Jeeyapant; B Vihokhern; RW van der Pluijm; Y Lubell; LJ White; R Aguas; C Promnarate; P Sirithiranont; B Malleret; L Rénia; C Onsjö; XH Chan; J Chalk; O Miotto; K Patumrat; K Chotivanich; B Hanboonkunupakarn; P Jittmala; N Kaehler; PY Cheah; C Pell; M Dhorda; M Imwong; G Snounou; M Mukaka; P Peerawaranun; SJ Lee; JA Simpson; S Pukrittayakamee; P Singhasivanon; MP Grobusch; F Cobelens; F Smithuis; PN Newton; GE Thwaites; NPJ Day; M Mayxay; TT Hien; FH Nosten; AM Dondorp; NJ White

Journal article

The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in southeast Asia: A cluster randomised trial

L von Seidlein, TJ Peto, J Landier, TN Nguyen, R Tripura, K Phommasone, T Pongvongsa, KM Lwin, L Keereecharoen, L Kajeechiwa, MM Thwin, DM Parker, J Wiladphaingern, S Nosten, S Proux, V Corbel, N Tuong-Vy, TL Phuc-Nhi, DH Son, PN Huong-Thu Show all

Plos Medicine | PUBLIC LIBRARY SCIENCE | Published : 2019

DOI: 10.1371/journal.pmed.1002745

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Abstract

Background The emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass drug administration (MDA), the presumptive antimalarial treatment of an entire population to clear the subclinical parasite reservoir, is a strategy to accelerate malaria elimination. We report a cluster randomised trial to assess the effectiveness of dihydroartemisinin-piperaquine (DP) MDA in reducing falciparum malaria incidence and prevalence in 16 remote village populations in Myanmar, Vietnam, Cambodia, and the Lao People’s Democratic Republic, where artemisinin resistance is prevalent. Methods and findings After establ..

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University of Melbourne Researchers

Julie Simpson Author

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INTEGRATION OF BIOSTATISTICS AND MATHEMATICAL MODELLING TO IMPROVE THE CONTROL OF INFECTIOUS DISEASES

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

NJW is the recipient of the Wellcome Trust Award Number: 101148/Z/13/Z. AMD is the recipient of the Bill and Melinda Gates Foundation Award Number: OPP1081420. JAS is the recipient of the National Health and Medical Research Council Award Number: 1104975. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.